Identification of NFAT5 as a transcriptional regulator of the EDN1 gene in collecting duct

The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na(+) and water reabsorption. Recent studies suggest that IMCD ET-1 production is enhanced by extracellular hypertonicity as can occur during high salt intake. Alth...

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Publicat a:Am J Physiol Renal Physiol
Autors principals: Lakshmipathi, Jayalakshmi, Wheatley, Will, Kumar, Anil, Mercenne, Gaelle, Rodan, Aylin R., Kohan, Donald E.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2019
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Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442376/
https://ncbi.nlm.nih.gov/pubmed/30623723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00509.2018
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