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Identification of NFAT5 as a transcriptional regulator of the EDN1 gene in collecting duct
The inner medullary collecting duct (IMCD) produces very high levels of endothelin-1 (ET-1) that acts as an autocrine inhibitor of IMCD Na(+) and water reabsorption. Recent studies suggest that IMCD ET-1 production is enhanced by extracellular hypertonicity as can occur during high salt intake. Alth...
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| Publicado no: | Am J Physiol Renal Physiol |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6442376/ https://ncbi.nlm.nih.gov/pubmed/30623723 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00509.2018 |
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