DNA damage repair alterations modulate M2 polarization of microglia to remodel the tumor microenvironment via the p53-mediated MDK expression in glioma

BACKGROUND: DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR alterations in glioma malignancy needs further investigation. This study aims to characterize the clinical and molecular features of gli...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Meng, Xiangqi, Duan, Chunbin, Pang, Hengyuan, Chen, Qun, Han, Bo, Zha, Caijun, Dinislam, Magafurov, Wu, Pengfei, Li, Ziwei, Zhao, Shihong, Wang, Ruijia, Lin, Lin, Jiang, Chuanlu, Cai, Jinquan
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
Soggetti:
Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6442002/
https://ncbi.nlm.nih.gov/pubmed/30773478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.067
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