Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity

Exposure to elevated levels of manganese (Mn) causes manganism, a neurological disorder with similar characteristics to those of Parkinson’s disease (PD). Valproic acid (VPA), an antiepileptic, is known to inhibit histone deacetylases and exert neuroprotective effects in many experimental models of...

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Publicado en:Neurotoxicology
Main Authors: Johnson, James, Pajarillo, Edward, Karki, Pratap, Kim, Judong, Son, Deok-Soo, Aschner, Michael, Lee, Eunsook
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441963/
https://ncbi.nlm.nih.gov/pubmed/29778792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2018.05.001
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