Valproic acid attenuates manganese-induced reduction in expression of GLT-1 and GLAST with concomitant changes in murine dopaminergic neurotoxicity

Exposure to elevated levels of manganese (Mn) causes manganism, a neurological disorder with similar characteristics to those of Parkinson’s disease (PD). Valproic acid (VPA), an antiepileptic, is known to inhibit histone deacetylases and exert neuroprotective effects in many experimental models of...

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Vydáno v:Neurotoxicology
Hlavní autoři: Johnson, James, Pajarillo, Edward, Karki, Pratap, Kim, Judong, Son, Deok-Soo, Aschner, Michael, Lee, Eunsook
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441963/
https://ncbi.nlm.nih.gov/pubmed/29778792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2018.05.001
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