17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity

Chronic exposure to manganese (Mn) causes neurotoxicity, referred to as manganism, with common clinical features of parkinsonism. 17β-estradiol (E2) and tamoxifen (TX), a selective estrogen receptor modulator (SERM), afford neuroprotection in several neurological disorders, including Parkinson’s dis...

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Vydáno v:Neurotoxicology
Hlavní autoři: Pajarillo, Edward, Johnson, James, Kim, Judong, Karki, Pratap, Son, Deok-Soo, Aschner, Michael, Lee, Eunsook
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5905416/
https://ncbi.nlm.nih.gov/pubmed/29183790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuro.2017.11.008
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