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Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice

IntroductionChronic manganese (Mn) overexposure causes manganism, a Parkinson’s disease-like neurological disorder, due to its preferential accumulation in the basal ganglia. Tamoxifen (TX), a selective estrogen receptor modulator (SERM), afforded neuroprotection against Mn toxicity, and RE1-silenci...

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Autori principali: Edward Pajarillo, Alexis Digman, Itunu Ajayi, Sanghoon Kim, Deok-Soo Son, Michael Aschner, Eunsook Lee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-10-01
Serie:Frontiers in Pharmacology
Soggetti:
epigenetic modulation
gene expression
histone acetylation
manganese
NRSF/REST
SERM
Accesso online:https://www.frontiersin.org/articles/10.3389/fphar.2025.1627400/full
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