Dopaminergic REST is implicated in the tamoxifen-induced neuroprotection against manganese toxicity in female mice

IntroductionChronic manganese (Mn) overexposure causes manganism, a Parkinson’s disease-like neurological disorder, due to its preferential accumulation in the basal ganglia. Tamoxifen (TX), a selective estrogen receptor modulator (SERM), afforded neuroprotection against Mn toxicity, and RE1-silenci...

Celý popis

Podrobná bibliografie

Hlavní autoři:	Edward Pajarillo, Alexis Digman, Itunu Ajayi, Sanghoon Kim, Deok-Soo Son, Michael Aschner, Eunsook Lee
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2025-10-01
Edice:	Frontiers in Pharmacology
Témata:	epigenetic modulation gene expression histone acetylation manganese NRSF/REST SERM
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1627400/full
Tagy:	Přidat tag Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!