Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma

BACKGROUND: Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. Despite intensive st...

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Foilsithe in:EBioMedicine
Main Authors: Siebenthall, Kyle T., Miller, Chris P., Vierstra, Jeff D., Mathieu, Julie, Tretiakova, Maria, Reynolds, Alex, Sandstrom, Richard, Rynes, Eric, Haugen, Eric, Johnson, Audra, Nelson, Jemma, Bates, Daniel, Diegel, Morgan, Dunn, Douglass, Frerker, Mark, Buckley, Michael, Kaul, Rajinder, Zheng, Ying, Himmelfarb, Jonathan, Ruohola-Baker, Hannele, Akilesh, Shreeram
Formáid: Artigo
Teanga:Inglês
Foilsithe: Elsevier 2019
Ábhair:
Research paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441874/
https://ncbi.nlm.nih.gov/pubmed/30827930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.063
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