Integrated epigenomic profiling reveals endogenous retrovirus reactivation in renal cell carcinoma

BACKGROUND: Transcriptional dysregulation drives cancer formation but the underlying mechanisms are still poorly understood. Renal cell carcinoma (RCC) is the most common malignant kidney tumor which canonically activates the hypoxia-inducible transcription factor (HIF) pathway. Despite intensive st...

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Dettagli Bibliografici
Pubblicato in:EBioMedicine
Autori principali: Siebenthall, Kyle T., Miller, Chris P., Vierstra, Jeff D., Mathieu, Julie, Tretiakova, Maria, Reynolds, Alex, Sandstrom, Richard, Rynes, Eric, Haugen, Eric, Johnson, Audra, Nelson, Jemma, Bates, Daniel, Diegel, Morgan, Dunn, Douglass, Frerker, Mark, Buckley, Michael, Kaul, Rajinder, Zheng, Ying, Himmelfarb, Jonathan, Ruohola-Baker, Hannele, Akilesh, Shreeram
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
Soggetti:
Research paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441874/
https://ncbi.nlm.nih.gov/pubmed/30827930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2019.01.063
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