Global reference mapping of human transcription factor footprints

Combinatorial binding of transcription factors to regulatory DNA underpins gene regulation in all organisms. Genetic variation in regulatory regions has been connected with diseases and diverse phenotypic traits(1), but it remains challenging to distinguish variants that affect regulatory function(2...

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Détails bibliographiques
Publié dans:Nature
Auteurs principaux: Vierstra, Jeff, Lazar, John, Sandstrom, Richard, Halow, Jessica, Lee, Kristen, Bates, Daniel, Diegel, Morgan, Dunn, Douglas, Neri, Fidencio, Haugen, Eric, Rynes, Eric, Reynolds, Alex, Nelson, Jemma, Johnson, Audra, Frerker, Mark, Buckley, Michael, Kaul, Rajinder, Meuleman, Wouter, Stamatoyannopoulos, John A.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7410829/
https://ncbi.nlm.nih.gov/pubmed/32728250
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-020-2528-x
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