Antimycin A-Induced Mitochondrial Damage Causes Human RPE Cell Death despite Activation of Autophagy

Mitochondrial dysfunction has been implicated in a wide variety of degenerative diseases, including age-related macular degeneration. Damage to mitochondria and mitochondrial DNA accumulates with age in the postmitotic retinal pigment epithelium (RPE), which could lead to RPE cell death and trigger...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Hytti, Maria, Korhonen, Eveliina, Hyttinen, Juha M. T., Roehrich, Heidi, Kaarniranta, Kai, Ferrington, Deborah A., Kauppinen, Anu
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6441541/
https://ncbi.nlm.nih.gov/pubmed/31007832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/1583656
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