Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis

Calreticulin (CALR) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate signal transducer and activator of transcription (STAT) proteins in the presence of Myeloproliferative Leukemia Virus (MPL) and induce ET in vivo. Loss of...

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Publicat a:Blood Cancer J
Autors principals: Shide, Kotaro, Kameda, Takuro, Kamiunten, Ayako, Oji, Asami, Ozono, Yoshinori, Sekine, Masaaki, Honda, Arata, Kitanaka, Akira, Akizuki, Keiichi, Tahira, Yuki, Nakamura, Kenichi, Hidaka, Tomonori, Kubuki, Yoko, Abe, Hiroo, Miike, Tadashi, Iwakiri, Hisayoshi, Tahara, Yoshihiro, Sueta, Mitsue, Hasuike, Satoru, Yamamoto, Shojiro, Nagata, Kenji, Ikawa, Masahito, Shimoda, Kazuya
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440999/
https://ncbi.nlm.nih.gov/pubmed/30926777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-019-0202-z
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