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Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis
Calreticulin (CALR) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate signal transducer and activator of transcription (STAT) proteins in the presence of Myeloproliferative Leukemia Virus (MPL) and induce ET in vivo. Loss of...
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| 出版年: | Blood Cancer J |
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| 主要な著者: | , , , , , , , , , , , , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Nature Publishing Group UK
2019
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| 主題: | |
| オンライン・アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6440999/ https://ncbi.nlm.nih.gov/pubmed/30926777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-019-0202-z |
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