Mice with Calr mutations homologous to human CALR mutations only exhibit mild thrombocytosis

Calreticulin (CALR) exon 9 frameshift mutations, commonly detected in essential thrombocythemia (ET) and primary myelofibrosis patients, activate signal transducer and activator of transcription (STAT) proteins in the presence of Myeloproliferative Leukemia Virus (MPL) and induce ET in vivo. Loss of...

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Bibliografiske detaljer
Udgivet i:Blood Cancer J
Main Authors: Shide, Kotaro, Kameda, Takuro, Kamiunten, Ayako, Oji, Asami, Ozono, Yoshinori, Sekine, Masaaki, Honda, Arata, Kitanaka, Akira, Akizuki, Keiichi, Tahira, Yuki, Nakamura, Kenichi, Hidaka, Tomonori, Kubuki, Yoko, Abe, Hiroo, Miike, Tadashi, Iwakiri, Hisayoshi, Tahara, Yoshihiro, Sueta, Mitsue, Hasuike, Satoru, Yamamoto, Shojiro, Nagata, Kenji, Ikawa, Masahito, Shimoda, Kazuya
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440999/
https://ncbi.nlm.nih.gov/pubmed/30926777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41408-019-0202-z
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