Calreticulin mutant mice develop essential thrombocythemia that is ameliorated by the JAK inhibitor ruxolitinib

Mutations of calreticulin (CALR) are detected in 25–30% of patients with essential thrombocythemia (ET) or primary myelofibrosis and cause frameshifts that result in proteins with a novel C-terminal. We demonstrate that CALR mutations activated signal transducer and activator of transcription 5 (STA...

Полное описание

Сохранить в:
Библиографические подробности
Опубликовано в: :Leukemia
Главные авторы: Shide, K, Kameda, T, Yamaji, T, Sekine, M, Inada, N, Kamiunten, A, Akizuki, K, Nakamura, K, Hidaka, T, Kubuki, Y, Shimoda, H, Kitanaka, A, Honda, A, Sawaguchi, A, Abe, H, Miike, T, Iwakiri, H, Tahara, Y, Sueta, M, Hasuike, S, Yamamoto, S, Nagata, K, Shimoda, K
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group 2017
Предметы:
Original Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420793/
https://ncbi.nlm.nih.gov/pubmed/27807369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2016.308
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы