Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice

Mutations in JAK2, myeloproliferative leukemia virus (MPL), or calreticulin (CALR) occur in hematopoietic stem cells (HSCs) and are detected in more than 80% of patients with myeloproliferative neoplasms (MPNs). They are thought to play a driver role in MPN pathogenesis via autosomal activation of t...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Shide, Kotaro, Kameda, Takuro, Kamiunten, Ayako, Ozono, Yoshinori, Tahira, Yuki, Yokomizo-Nakano, Takako, Kubota, Sho, Ono, Masaya, Ikeda, Kazuhiko, Sekine, Masaaki, Akizuki, Keiichi, Nakamura, Kenichi, Hidaka, Tomonori, Kubuki, Yoko, Iwakiri, Hisayoshi, Hasuike, Satoru, Nagata, Kenji, Sashida, Goro, Shimoda, Kazuya
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2020
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332892/
https://ncbi.nlm.nih.gov/pubmed/32219445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003358
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