Calreticulin haploinsufficiency augments stem cell activity and is required for onset of myeloproliferative neoplasms in mice

Mutations in JAK2, myeloproliferative leukemia virus (MPL), or calreticulin (CALR) occur in hematopoietic stem cells (HSCs) and are detected in more than 80% of patients with myeloproliferative neoplasms (MPNs). They are thought to play a driver role in MPN pathogenesis via autosomal activation of t...

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Enregistré dans:
Détails bibliographiques
Publié dans:Blood
Auteurs principaux: Shide, Kotaro, Kameda, Takuro, Kamiunten, Ayako, Ozono, Yoshinori, Tahira, Yuki, Yokomizo-Nakano, Takako, Kubota, Sho, Ono, Masaya, Ikeda, Kazuhiko, Sekine, Masaaki, Akizuki, Keiichi, Nakamura, Kenichi, Hidaka, Tomonori, Kubuki, Yoko, Iwakiri, Hisayoshi, Hasuike, Satoru, Nagata, Kenji, Sashida, Goro, Shimoda, Kazuya
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2020
Sujets:
Myeloid Neoplasia
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7332892/
https://ncbi.nlm.nih.gov/pubmed/32219445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood.2019003358
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