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A molecular dynamics investigation of CDK8/CycC and ligand binding: conformational flexibility and implication in drug discovery
Abnormal activity of cyclin-dependent kinase 8 (CDK8) along with its partner protein cyclin C (CycC) is a common feature of many diseases including colorectal cancer. Using molecular dynamics (MD) simulations, this study determined the dynamics of the CDK8-CycC system and we obtained detailed breakd...
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| 發表在: | J Comput Aided Mol Des |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2018
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6440799/ https://ncbi.nlm.nih.gov/pubmed/29737445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10822-018-0120-3 |
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