Affibody-Mediated Sequestration of Amyloid β Demonstrates Preventive Efficacy in a Transgenic Alzheimer’s Disease Mouse Model

Different strategies for treatment and prevention of Alzheimer’s disease (AD) are currently under investigation, including passive immunization with anti-amyloid β (anti-Aβ) monoclonal antibodies (mAbs). Here, we investigate the therapeutic potential of a novel type of Aβ-targeting agent based on an...

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Bibliographische Detailangaben
Veröffentlicht in:Front Aging Neurosci
Hauptverfasser: Boutajangout, Allal, Lindberg, Hanna, Awwad, Abdulaziz, Paul, Arun, Baitalmal, Rabaa, Almokyad, Ismail, Höidén-Guthenberg, Ingmarie, Gunneriusson, Elin, Frejd, Fredrik Y., Härd, Torleif, Löfblom, John, Ståhl, Stefan, Wisniewski, Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6440316/
https://ncbi.nlm.nih.gov/pubmed/30967771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00064
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