Molecular Basis of Broad Spectrum N-Glycan Specificity and Processing of Therapeutic IgG Monoclonal Antibodies by Endoglycosidase S2

[Image: see text] Immunoglobulin G (IgG) glycosylation critically modulates antibody effector functions. Streptococcus pyogenes secretes a unique endo-β-N-acetylglucosaminidase, EndoS2, which deglycosylates the conserved N-linked glycan at Asn297 on IgG Fc to eliminate its effector functions and eva...

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Detalhes bibliográficos
Publicado no:ACS Cent Sci
Main Authors: Klontz, Erik H., Trastoy, Beatriz, Deredge, Daniel, Fields, James K., Li, Chao, Orwenyo, Jared, Marina, Alberto, Beadenkopf, Robert, Günther, Sebastian, Flores, Jair, Wintrode, Patrick L., Wang, Lai-Xi, Guerin, Marcelo E., Sundberg, Eric J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2019
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6439443/
https://ncbi.nlm.nih.gov/pubmed/30937380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.8b00917
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