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Ablation of the Chaperone Protein ERdj5 Results in a Sjögren's Syndrome-Like Phenotype in Mice, Consistent With an Upregulated Unfolded Protein Response in Human Patients

Objective: Sjögren's syndrome (SS) is a chronic autoimmune disorder that affects mainly the exocrine glands. Endoplasmic reticulum (ER) stress proteins have been suggested to participate in autoimmune and inflammatory responses, either acting as autoantigens, or by modulating factors of inflamm...

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Bibliografski detalji
Izdano u:Front Immunol
Glavni autori: Apostolou, Eirini, Moustardas, Petros, Iwawaki, Takao, Tzioufas, Athanasios G., Spyrou, Giannis
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438897/
https://ncbi.nlm.nih.gov/pubmed/30967862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00506
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