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Total Synthesis and Anticancer Activity of (+)-Hypercalin C and Congeners

The hypercalins are dearomatized acylphloroglucinols with a pendant complex cyclopentane ring that exhibit activity against several cancer cell lines. We report the first total synthesis of (+)-hypercalin C employing a convergent strategy that enabled dissection of the essential structural features...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Tao, Yongfeng, Reisenauer, Keighley, Taube, Joseph H., Romo, Daniel
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438696/
https://ncbi.nlm.nih.gov/pubmed/30600887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201812909
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