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Total synthesis of phenanthroindolizidine alkaloids (±)-antofine, (±)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity

Due to their limited natural abundance and significant biochemical effects, we synthesized the alkaloids (±)-antofine (1a), (±)-deoxypergularinine (1b), and their dehydro congeners (2 and 3) starting from the corresponding phenanthrene-9-carboxaldehydes. We also evaluated their in vitro cytotoxic ac...

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Dettagli Bibliografici
Autori principali: Su, Chung-Ren, Damu, Amooru G., Chiang, Po-Cheng, Bastow, Kenneth F., Morris-Natschke, Susan L., Lee, Kuo-Hsiung, Wu, Tian-Shung
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2577820/
https://ncbi.nlm.nih.gov/pubmed/18456501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.04.032
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