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Pharmacophore-Directed Retrosynthesis Applied to Ophiobolin A: Simplified Bicyclic Derivatives Displaying Anticancer Activity

Pharmacophore-directed retrosynthesis applied to ophiobolin A led to bicyclic derivatives that were synthesized and display anticancer activity. Key features of the ultimate defensive synthetic strategy include a Michael addition/facially-selective protonation sequence to set the critical C6 stereoc...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Org Lett
Egile Nagusiak: Tao, Yongfeng, Reisenauer, Keighley, Masi, Marco, Evidente, Antonio, Taube, Joseph H., Romo, Daniel
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7655722/
https://ncbi.nlm.nih.gov/pubmed/33034457
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02938
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