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Pharmacophore-Directed Retrosynthesis Applied to Ophiobolin A: Simplified Bicyclic Derivatives Displaying Anticancer Activity
Pharmacophore-directed retrosynthesis applied to ophiobolin A led to bicyclic derivatives that were synthesized and display anticancer activity. Key features of the ultimate defensive synthetic strategy include a Michael addition/facially-selective protonation sequence to set the critical C6 stereoc...
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| Izdano u: | Org Lett |
|---|---|
| Glavni autori: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2020
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7655722/ https://ncbi.nlm.nih.gov/pubmed/33034457 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.orglett.0c02938 |
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