Do Opiate Antagonists Interfere with the Clinical Benefits of Stimulants in ADHD? A Double-Blind, Placebo-Controlled Trial of the Mixed Opioid Receptor Antagonist Naltrexone

OBJECTIVE: Methylphenidate (MPH) activates mu opioid receptors, which are linked to euphoria. Mu opioid antagonists, such as naltrexone, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential. This study assessed whether the combination of naltrexone with MPH is w...

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Bibliografiske detaljer
Udgivet i:J Clin Psychiatry
Main Authors: Spencer, Thomas J., Bhide, Pradeep, Zhu, Jinmin, Faraone, Stephen V., Fitzgerald, Maura, Yule, Amy M., Uchida, Mai, Spencer, Andrea E., Anna Hall, M, Koster, Ariana J., Biederman, Joseph
Format: Artigo
Sprog:Inglês
Udgivet: 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6438372/
https://ncbi.nlm.nih.gov/pubmed/28640990
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/JCP.16m11012
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