Does the Mixed Opioid Receptor Antagonist Naltrexone Mitigate Stimulant-Induced Euphoria?: A Double-Blind, Placebo Controlled Trial of Naltrexone

OBJECTIVE: Supra therapeutic doses of methylphenidate (MPH) activate mu opioid receptors, which are linked to euphoria. This study assessed whether naltrexone, a mixed mu opioid antagonist, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential in subjects with At...

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Veröffentlicht in:J Clin Psychiatry
Hauptverfasser: Spencer, Thomas J., Bhide, Pradeep, Zhu, Jinmin, Faraone, Stephen V., Fitzgerald, Maura, Yule, Amy M., Uchida, Mai, Spencer, Andrea E., Hall, Anna M., Koster, Ariana J., Feinberg, Leah, Kassabian, Sarah, Storch, Barbara, Biederman, Joseph
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548180/
https://ncbi.nlm.nih.gov/pubmed/29617066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/JCP.17m11609
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