Does the Mixed Opioid Receptor Antagonist Naltrexone Mitigate Stimulant-Induced Euphoria?: A Double-Blind, Placebo Controlled Trial of Naltrexone

OBJECTIVE: Supra therapeutic doses of methylphenidate (MPH) activate mu opioid receptors, which are linked to euphoria. This study assessed whether naltrexone, a mixed mu opioid antagonist, may attenuate the euphoric effects of stimulants, thereby minimizing their abuse potential in subjects with At...

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Detalhes bibliográficos
Publicado no:J Clin Psychiatry
Main Authors: Spencer, Thomas J., Bhide, Pradeep, Zhu, Jinmin, Faraone, Stephen V., Fitzgerald, Maura, Yule, Amy M., Uchida, Mai, Spencer, Andrea E., Hall, Anna M., Koster, Ariana J., Feinberg, Leah, Kassabian, Sarah, Storch, Barbara, Biederman, Joseph
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6548180/
https://ncbi.nlm.nih.gov/pubmed/29617066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4088/JCP.17m11609
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