Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity

BACKGROUND: Mutations of the SCN2A gene encoding a voltage-gated sodium channel alpha-II subunit Nav1.2 are associated with neurological disorders such as epilepsy, autism spectrum disorders, intellectual disability, and schizophrenia. However, causal relationships and pathogenic mechanisms underlyi...

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Bibliographic Details
Published in:	Mol Autism
Main Authors:	Tatsukawa, Tetsuya, Raveau, Matthieu, Ogiwara, Ikuo, Hattori, Satoko, Miyamoto, Hiroyuki, Mazaki, Emi, Itohara, Shigeyoshi, Miyakawa, Tsuyoshi, Montal, Mauricio, Yamakawa, Kazuhiro
Format:	Artigo
Language:	Inglês
Published:	BioMed Central 2019
Subjects:	Research
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC6437867/ https://ncbi.nlm.nih.gov/pubmed/30962870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-019-0265-5
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Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity

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