Scn2a haploinsufficient mice display a spectrum of phenotypes affecting anxiety, sociability, memory flexibility and ampakine CX516 rescues their hyperactivity

BACKGROUND: Mutations of the SCN2A gene encoding a voltage-gated sodium channel alpha-II subunit Nav1.2 are associated with neurological disorders such as epilepsy, autism spectrum disorders, intellectual disability, and schizophrenia. However, causal relationships and pathogenic mechanisms underlyi...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Mol Autism
Egile Nagusiak: Tatsukawa, Tetsuya, Raveau, Matthieu, Ogiwara, Ikuo, Hattori, Satoko, Miyamoto, Hiroyuki, Mazaki, Emi, Itohara, Shigeyoshi, Miyakawa, Tsuyoshi, Montal, Mauricio, Yamakawa, Kazuhiro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: BioMed Central 2019
Gaiak:
Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437867/
https://ncbi.nlm.nih.gov/pubmed/30962870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-019-0265-5
Etiketak: Etiketa erantsi
Etiketarik gabe, Izan zaitez lehena erregistro honi etiketa jartzen!

Antzeko izenburuak