In Vitro Activity of Tebipenem (SPR859) against Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

Tebipenem (SPR859) is the microbiologically active form of SPR994 (tebipenem-pivoxil), an orally available carbapenem with activity against extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae. Measurement of the relative binding of SPR859 to the bacterial cell targets revealed that it...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Lacasse, Evelyne, Brouillette, Eric, Larose, Audrey, Parr, Thomas R., Rubio, Aileen, Malouin, François
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2019
Témata:
Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6437484/
https://ncbi.nlm.nih.gov/pubmed/30718255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02181-18
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