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Distinctive Binding of Avibactam to Penicillin-Binding Proteins of Gram-Negative and Gram-Positive Bacteria

Avibactam is a novel non-β-lactam β-lactamase inhibitor that covalently acylates a variety of β-lactamases, causing inhibition. Although avibactam presents limited antibacterial activity, its acylation ability toward bacterial penicillin-binding proteins (PBPs) was investigated. Staphylococcus aureu...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Asli, Abdelhamid, Brouillette, Eric, Krause, Kevin M., Nichols, Wright W., Malouin, François
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4750707/
https://ncbi.nlm.nih.gov/pubmed/26574008
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02102-15
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