1565. Characterization of Tebipenem (SPR859) Pharmacokinetics–Pharmacodynamics (PK-PD) for Efficacy Against Enterobacteriaceae in a One-Compartment In Vitro Infection Model

BACKGROUND: SPR859 (tebipenem) is the active form of the orally bioavailable prodrug SPR994. Tebipenem is an oral carbapenem with a broad-spectrum activity against Gram-positive and -negative bacteria. SPR994 is being developed as an oral option for the treatment of complicated urinary tract infecti...

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Publicado en:Open Forum Infect Dis
Autores principales: VanScoy, Brian D, Onufrak, Nikolas J, Conde, Haley, Caranco, Ana I, Bhavnani, Sujata M, Cotroneo, Nicole, Critchley, Ian A, Parr, Thomas R, Ambrose, Paul G
Formato: Artigo
Lenguaje:Inglês
Publicado: Oxford University Press 2019
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6810112/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ofid/ofz360.1429
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