T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy

Across clinical trials, T cell expansion and persistence following adoptive cell transfer (ACT) have correlated with superior patient outcomes. Herein, we undertook a pan-cancer analysis to identify actionable ligand-receptor pairs capable of compromising T cell durability following ACT. We discover...

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Udgivet i:J Clin Invest
Main Authors: Yamamoto, Tori N., Lee, Ping-Hsien, Vodnala, Suman K., Gurusamy, Devikala, Kishton, Rigel J., Yu, Zhiya, Eidizadeh, Arash, Eil, Robert, Fioravanti, Jessica, Gattinoni, Luca, Kochenderfer, James N., Fry, Terry J., Aksoy, Bulent Arman, Hammerbacher, Jeffrey E., Cruz, Anthony C., Siegel, Richard M., Restifo, Nicholas P., Klebanoff, Christopher A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436880/
https://ncbi.nlm.nih.gov/pubmed/30694219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121491
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