T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy

Across clinical trials, T cell expansion and persistence following adoptive cell transfer (ACT) have correlated with superior patient outcomes. Herein, we undertook a pan-cancer analysis to identify actionable ligand-receptor pairs capable of compromising T cell durability following ACT. We discover...

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Detalhes bibliográficos
Publicado no:J Clin Invest
Main Authors: Yamamoto, Tori N., Lee, Ping-Hsien, Vodnala, Suman K., Gurusamy, Devikala, Kishton, Rigel J., Yu, Zhiya, Eidizadeh, Arash, Eil, Robert, Fioravanti, Jessica, Gattinoni, Luca, Kochenderfer, James N., Fry, Terry J., Aksoy, Bulent Arman, Hammerbacher, Jeffrey E., Cruz, Anthony C., Siegel, Richard M., Restifo, Nicholas P., Klebanoff, Christopher A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436880/
https://ncbi.nlm.nih.gov/pubmed/30694219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI121491
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