COMBINATION POTENTIATOR (‘CO-POTENTIATOR’) THERAPY FOR CF CAUSED BY CFTR MUTANTS, INCLUDING N1303K, THAT ARE POORLY RESPONSIVE TO SINGLE POTENTIATORS

BACKGROUND: Current modulator therapies for some cystic fibrosis-causing CFTR mutants, including N1303K, have limited efficacy. We provide evidence here to support combination potentiator (co-potentiator) therapy for mutant CFTRs that are poorly responsive to single potentiators. METHODS: Functional...

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Detalhes bibliográficos
Publicado no:J Cyst Fibros
Main Authors: Phuan, Puay-Wah, Son, Jung-Ho, Tan, Joseph-Anthony, Li, Clarabella, Musante, Ilaria, Zlock, Lorna, Nielson, Dennis W., Finkbeiner, Walter E., Kurth, Mark J., Galietta, Luis J., Haggie, Peter M., Verkman, Alan S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436558/
https://ncbi.nlm.nih.gov/pubmed/29903467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcf.2018.05.010
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