Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis

Pendrin (SLC26A4) is a Cl(−)/anion exchanger expressed in the epithelium of inflamed airways where it is thought to facilitate Cl(−) absorption and HCO(3)(−) secretion. Studies using pendrin knockout mice and airway epithelial cells from hearing-impaired subjects with pendrin loss of function sugges...

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Detalhes bibliográficos
Publicado no:FASEB J
Main Authors: Haggie, Peter M., Phuan, Puay-Wah, Tan, Joseph-Anthony, Zlock, Lorna, Finkbeiner, Walter E., Verkman, A. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871793/
https://ncbi.nlm.nih.gov/pubmed/26932931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600223R
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