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Inhibitors of pendrin anion exchange identified in a small molecule screen increase airway surface liquid volume in cystic fibrosis
Pendrin (SLC26A4) is a Cl(−)/anion exchanger expressed in the epithelium of inflamed airways where it is thought to facilitate Cl(−) absorption and HCO(3)(−) secretion. Studies using pendrin knockout mice and airway epithelial cells from hearing-impaired subjects with pendrin loss of function sugges...
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| Veröffentlicht in: | FASEB J |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Federation of American Societies for Experimental Biology
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4871793/ https://ncbi.nlm.nih.gov/pubmed/26932931 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201600223R |
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