Thymic Epithelium Abnormalities in DiGeorge and Down Syndrome Patients Contribute to Dysregulation in T Cell Development

The thymus plays a fundamental role in establishing and maintaining central and peripheral tolerance and defects in thymic architecture or AIRE expression result in the development of autoreactive lymphocytes. Patients with partial DiGeorge Syndrome (pDGS) and Down Syndrome (DS) present alterations...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Marcovecchio, Genni Enza, Bortolomai, Ileana, Ferrua, Francesca, Fontana, Elena, Imberti, Luisa, Conforti, Erika, Amodio, Donato, Bergante, Sonia, Macchiarulo, Giulia, D'Oria, Veronica, Conti, Francesca, Di Cesare, Silvia, Fousteri, Georgia, Carotti, Adriano, Giamberti, Alessandro, Poliani, Pietro Luigi, Notarangelo, Luigi D., Cancrini, Caterina, Villa, Anna, Bosticardo, Marita
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6436073/
https://ncbi.nlm.nih.gov/pubmed/30949166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00447
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