Leveraging Spatial Variation in Tumor Purity for Improved Somatic Variant Calling of Archival Tumor Only Samples

Archival tumor samples represent a rich resource of annotated specimens for translational genomics research. However, standard variant calling approaches require a matched normal sample from the same individual, which is often not available in the retrospective setting, making it difficult to distin...

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Veröffentlicht in:Front Oncol
Hauptverfasser: Halperin, Rebecca F., Liang, Winnie S., Kulkarni, Sidharth, Tassone, Erica E., Adkins, Jonathan, Enriquez, Daniel, Tran, Nhan L., Hank, Nicole C., Newell, James, Kodira, Chinnappa, Korn, Ronald, Berens, Michael E., Kim, Seungchan, Byron, Sara A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2019
Schlagworte:
Oncology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435595/
https://ncbi.nlm.nih.gov/pubmed/30949446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00119
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