Leveraging Spatial Variation in Tumor Purity for Improved Somatic Variant Calling of Archival Tumor Only Samples

Archival tumor samples represent a rich resource of annotated specimens for translational genomics research. However, standard variant calling approaches require a matched normal sample from the same individual, which is often not available in the retrospective setting, making it difficult to distin...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Halperin, Rebecca F., Liang, Winnie S., Kulkarni, Sidharth, Tassone, Erica E., Adkins, Jonathan, Enriquez, Daniel, Tran, Nhan L., Hank, Nicole C., Newell, James, Kodira, Chinnappa, Korn, Ronald, Berens, Michael E., Kim, Seungchan, Byron, Sara A.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435595/
https://ncbi.nlm.nih.gov/pubmed/30949446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.00119
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