Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

Age-related macular degeneration (AMD) is a progressive disease of the retinal pigment epithelium (RPE) and the retina leading to loss of central vision. Polymorphisms in genes involved in lipid metabolism, including the ATP-binding cassette transporter A1 (ABCA1), have been associated with AMD risk...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Storti, Federica, Klee, Katrin, Todorova, Vyara, Steiner, Regula, Othman, Alaa, van der Velde-Visser, Saskia, Samardzija, Marijana, Meneau, Isabelle, Barben, Maya, Karademir, Duygu, Pauzuolyte, Valda, Boye, Sanford L, Blaser, Frank, Ullmer, Christoph, Dunaief, Joshua L, Hornemann, Thorsten, Rohrer, Lucia, den Hollander, Anneke, von Eckardstein, Arnold, Fingerle, Jürgen, Maugeais, Cyrille, Grimm, Christian
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2019
Assuntos:
Human Biology and Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6435327/
https://ncbi.nlm.nih.gov/pubmed/30864945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.45100
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