Foxp3(+) Regulatory and Conventional CD4(+) T Cells Display Similarly High Frequencies of Alloantigen-Reactive Cells

Foxp3(+) regulatory T cells (Tregs) play a major role in acquired immune tolerance to allogenic transplants. Their suppressive activity is thought to require T cell receptor (TCR)-driven antigen recognition; little, however, is known about the fraction of Tregs able to recognize alloantigens within...

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Vydáno v:Front Immunol
Hlavní autoři: Lalfer, Mélanie, Chappert, Pascal, Carpentier, Maxime, Urbain, Dominique, Davoust, Jean M., Gross, David-Alexandre
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Immunology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434998/
https://ncbi.nlm.nih.gov/pubmed/30941146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.00521
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