Intrinsic Transgene Immunogenicity Gears CD8(+) T-cell Priming After rAAV-Mediated Muscle Gene Transfer

Antitransgene CD8(+) T-cell responses are an important hurdle after recombinant adeno-associated virus (rAAV) vector-mediated gene transfer. Indeed, depending on the mutational genotype of the host, transgene amino-acid sequences of foreign origin can elicit deleterious cellular and humoral response...

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Detalhes bibliográficos
Publicado no:Mol Ther
Main Authors: Carpentier, Maxime, Lorain, Stéphanie, Chappert, Pascal, Lalfer, Mélanie, Hardet, Romain, Urbain, Dominique, Peccate, Cécile, Adriouch, Sahil, Garcia, Luis, Davoust, Jean, Gross, David-Alexandre
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4395773/
https://ncbi.nlm.nih.gov/pubmed/25492560
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.235
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