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Intrinsic Transgene Immunogenicity Gears CD8(+) T-cell Priming After rAAV-Mediated Muscle Gene Transfer
Antitransgene CD8(+) T-cell responses are an important hurdle after recombinant adeno-associated virus (rAAV) vector-mediated gene transfer. Indeed, depending on the mutational genotype of the host, transgene amino-acid sequences of foreign origin can elicit deleterious cellular and humoral response...
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| Izdano u: | Mol Ther |
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| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4395773/ https://ncbi.nlm.nih.gov/pubmed/25492560 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.235 |
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