Intradermal Immunization with rAAV1 Vector Induces Robust Memory CD8(+) T Cell Responses Independently of Transgene Expression in DCs

Recombinant adeno-associated viral (rAAV) vectors exhibit interesting properties as vaccine carriers for their ability to induce long-lasting antibody responses. However, rAAV-based vaccines have been suggested to trigger functionally impaired long-term memory CD8(+) T cell responses, in part due to...

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Bibliografische gegevens
Gepubliceerd in:Mol Ther
Hoofdauteurs: Ghenassia, Alexandre, Gross, David-Alexandre, Lorain, Stéphanie, Tros, Fabiola, Urbain, Dominique, Benkhelifa-Ziyyat, Sofia, Charbit, Alain, Davoust, Jean, Chappert, Pascal
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society of Gene & Cell Therapy 2017
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Original Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5628776/
https://ncbi.nlm.nih.gov/pubmed/28720467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.06.019
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