The chaperone protein HSP47: a platelet collagen binding protein that contributes to thrombosis and hemostasis

ESSENTIALS: Heat shock protein 47 (HSP47), a collagen specific chaperone is present on the platelet surface. Collagen mediated platelet function was reduced following blockade or deletion of HSP47. GPVI receptor regulated signalling was reduced in HSP47 deficient platelets. Platelet HSP47 tethers to...

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Publicado no:J Thromb Haemost
Main Authors: Sasikumar, P., AlOuda, K. S., Kaiser, W. J., Holbrook, L. M., Kriek, N., Unsworth, A. J., Bye, A. P., Sage, T., Ushioda, R., Nagata, K., Farndale, R. W., Gibbins, J. M.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434988/
https://ncbi.nlm.nih.gov/pubmed/29512284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.13998
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