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The HCM-causing Y235S cMyBPC mutation accelerates contractile function by altering C1 domain structure
Mutations in cardiac myosin binding protein C (cMyBPC) are a major cause of hypertrophic cardiomyopathy (HCM). In particular, a single amino acid substitution of tyrosine to serine at residue 237 in humans (residue 235 in mice) has been linked to HCM with strong disease association. Although cMyBPC...
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| Vydáno v: | Biochim Biophys Acta Mol Basis Dis |
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| Hlavní autoři: | , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2019
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6434951/ https://ncbi.nlm.nih.gov/pubmed/30611859 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2019.01.007 |
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