Length-dependent changes in contractile dynamics are blunted due to cardiac myosin binding protein-C ablation

Enhanced cardiac contractile function with increased sarcomere length (SL) is, in part, mediated by a decrease in the radial distance between myosin heads and actin. The radial disposition of myosin heads relative to actin is modulated by cardiac myosin binding protein-C (cMyBP-C), suggesting that c...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Mamidi, Ranganath, Gresham, Kenneth S., Stelzer, Julian E.
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2014
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4251301/
https://ncbi.nlm.nih.gov/pubmed/25520665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2014.00461
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