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cMyBPC phosphorylation modulates the effect of omecamtiv mecarbil on myocardial force generation
Omecamtiv mecarbil (OM), a direct myosin motor activator, is currently being tested as a therapeutic replacement for conventional inotropes in heart failure (HF) patients. It is known that HF patients exhibit dysregulated β-adrenergic signaling and decreased cardiac myosin-binding protein C (cMyBPC)...
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| Udgivet i: | J Gen Physiol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Rockefeller University Press
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7953254/ https://ncbi.nlm.nih.gov/pubmed/33688929 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.202012816 |
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