Dose-Dependent Effects of the Myosin Activator Omecamtiv Mecarbil on Cross-Bridge Behavior and Force Generation in Failing Human Myocardium

BACKGROUND: Omecamtiv mecarbil (OM) enhances systolic function in vivo by directly binding the myosin cross-bridges (XBs) in the sarcomere. However, the mechanistic details governing OM-induced modulation of XB behavior in failing human myocardium are unclear. METHODS AND RESULTS: The effects of OM...

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Vydáno v:Circ Heart Fail
Hlavní autoři: Mamidi, Ranganath, Li, Jiayang, Gresham, Kenneth S., Verma, Sujeet, Doh, Chang Yoon, Li, Amy, Lal, Sean, dos Remedios, Cristobal G., Stelzer, Julian E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5685665/
https://ncbi.nlm.nih.gov/pubmed/29030372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCHEARTFAILURE.117.004257
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