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Insulin Receptor Substrate Suppression by the Tyrphostin NT157 Inhibits Responses to Insulin-Like Growth Factor-I and Insulin in Breast Cancer Cells

Insulin and insulin-like growth factor (IGF) signaling systems regulate breast cancer growth, progression, and metastasis. The insulin receptor substrates 1 and 2 (IRS1/2) transduce signaling from the type I IGF receptor (IGF-IR) and insulin receptor (InR) to mediate the biological effects of recept...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Horm Cancer
Main Authors: Yang, Yuzhe, Chan, Jie Ying, Temiz, Nuri A., Yee, Douglas
Format: Artigo
Jezik:Inglês
Izdano: Springer US 2018
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6434949/
https://ncbi.nlm.nih.gov/pubmed/30229539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12672-018-0343-8
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