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Targeting insulin receptor in breast cancer using small engineered protein scaffolds

Insulin receptor (InsR) and the type I insulin-like growth factor (IGF1R) are homologous receptors necessary for signal transduction by their cognate ligands insulin, insulin-like growth factor-I and –II (IGF-I and IGF-II). IGF1R monoclonal antibodies, intended to inhibit malignant phenotypic signal...

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Bibliografiske detaljer
Udgivet i:Mol Cancer Ther
Main Authors: Chan, Jie Ying, Hackel, Benjamin J., Yee, Douglas
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5518922/
https://ncbi.nlm.nih.gov/pubmed/28468775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-16-0685
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