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Disease-associated mutations of claudin-19 disrupt retinal neurogenesis and visual function

Mutations of claudin-19 cause Familial Hypomagnesaemia and Hypercalciuria, Nephrocalcinosis with Ocular Involvement. To study the ocular disease without the complications of the kidney disease, naturally occurring point mutations of human CLDN19 were recreated in human induced pluripotent cells or o...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Commun Biol
Hauptverfasser: Wang, Shao-Bin, Xu, Tao, Peng, Shaomin, Singh, Deepti, Ghiassi-Nejad, Maryam, Adelman, Ron A., Rizzolo, Lawrence J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433901/
https://ncbi.nlm.nih.gov/pubmed/30937396
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0355-0
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