Histone deacetylase inhibitor LMK235 attenuates vascular constriction and aortic remodelling in hypertension

Here, we report that LMK235, a class I and histone deacetylase (HDAC6)‐preferential HDAC inhibitor, reduces hypertension via inhibition of vascular contraction and vessel hypertrophy. Angiotensin II‐infusion mice and spontaneously hypertensive rats (SHRs) were used to test the anti‐hypertensive effe...

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Detaylı Bibliyografya
Yayımlandı:J Cell Mol Med
Asıl Yazarlar: Choi, Sin Young, Kee, Hae Jin, Sun, Simei, Seok, Young Mi, Ryu, Yuhee, Kim, Gwi Ran, Kee, Seung‐Jung, Pflieger, Marc, Kurz, Thomas, Kassack, Matthias U., Jeong, Myung Ho
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Original Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6433685/
https://ncbi.nlm.nih.gov/pubmed/30734467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14188
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